Active Ingredient: Vancomycin
Vancomycin is indicated in all age groups for the treatment of Clostridium difficile infection (CDI).
Oral administration: consideration should be given to discontinuing proton pump inhibitors and anti-motility agents in line with local guidelines for Clostridium Difficile infection.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
500 - 2,000 mg
From 125 To 500 mg 4 time(s) per day every day for 10 day(s)
The recommended vancomycin dose is 125 mg every 6 hours for 10 days for the first episode of non-severe CDI. This dose can be increased to 500 mg every 6 hours for 10 days in case of severe or complicated disease. The maximum daily dose should not exceed 2 g.
In patients with multiple recurrences, consideration may be given to treat the current episode of CDI with vancomycin, 125 mg four times daily for 10 days followed by either tapering the dose, i.e. gradually decreasing it until 125 mg per day or a pulse regimen, i.e. 125–500 mg/day every 2–3 days for at least 3 weeks.
Vancomycin shall only be administered as slow intravenous infusion of at least one hour duration or at a maximum rate of 10 mg/min (whichever is longer) which is sufficiently diluted (at least 100 ml per 500 mg or at least 200 ml per 1,000 mg).
Oral
500 - 2,000 mg
From 125 To 500 mg 4 time(s) per day every day for 10 day(s)
The recommended vancomycin dose is 125 mg every 6 hours for 10 days for the first episode of non-severe CDI. This dose can be increased to 500 mg every 6 hours for 10 days in case of severe or complicated disease. The maximum daily dose should not exceed 2 g.
In patients with multiple recurrences, consideration may be given to treat the current episode of CDI with vancomycin, 125 mg four times daily for 10 days followed by either tapering the dose, i.e. gradually decreasing it until 125 mg per day or a pulse regimen, i.e. 125–500 mg/day every 2–3 days for at least 3 weeks.
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