Clostridium difficile infection (CDI)

Indication for Vancomycin

Population group: Suitable for both men and women, only adolescents (12 years - 18 years old) , adults (18 years old or older)

Vancomycin is indicated in all age groups for the treatment of Clostridium difficile infection (CDI).

Oral administration: consideration should be given to discontinuing proton pump inhibitors and anti-motility agents in line with local guidelines for Clostridium Difficile infection.

For this indication, competent medicine agencies globally authorize below treatments:

500-2,000 mg in 4 divided doses daily

Route of admnistration

Intravenous

Defined daily dose

500 - 2,000 mg

Dosage regimen

From 125 To 500 mg 4 time(s) per day every day for 10 day(s)

Detailed description

The recommended vancomycin dose is 125 mg every 6 hours for 10 days for the first episode of non-severe CDI. This dose can be increased to 500 mg every 6 hours for 10 days in case of severe or complicated disease. The maximum daily dose should not exceed 2 g.

In patients with multiple recurrences, consideration may be given to treat the current episode of CDI with vancomycin, 125 mg four times daily for 10 days followed by either tapering the dose, i.e. gradually decreasing it until 125 mg per day or a pulse regimen, i.e. 125–500 mg/day every 2–3 days for at least 3 weeks.

Dosage considerations

Vancomycin shall only be administered as slow intravenous infusion of at least one hour duration or at a maximum rate of 10 mg/min (whichever is longer) which is sufficiently diluted (at least 100 ml per 500 mg or at least 200 ml per 1,000 mg).

500-2,000 mg in 4 divided doses daily

Route of admnistration

Oral

Defined daily dose

500 - 2,000 mg

Dosage regimen

From 125 To 500 mg 4 time(s) per day every day for 10 day(s)

Detailed description

The recommended vancomycin dose is 125 mg every 6 hours for 10 days for the first episode of non-severe CDI. This dose can be increased to 500 mg every 6 hours for 10 days in case of severe or complicated disease. The maximum daily dose should not exceed 2 g.

In patients with multiple recurrences, consideration may be given to treat the current episode of CDI with vancomycin, 125 mg four times daily for 10 days followed by either tapering the dose, i.e. gradually decreasing it until 125 mg per day or a pulse regimen, i.e. 125–500 mg/day every 2–3 days for at least 3 weeks.

Active ingredient

Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units.

Read more about Vancomycin

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