Supraventricular arrhythmia, re-entrant atrioventricular node tachycardia, Wolff-Parkinson-White pattern

Active Ingredient: Flecainide

Indication for Flecainide

Population group: only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Treatment of AV nodal reciprocating tachycardia; arrhythmias associated with Wolff-Parkinson-White Syndrome and similar conditions with accessory pathways, when other treatment has been ineffective.

Treatment of paroxysmal atrial arrhythmias (atrial fibrillation, atrial flutter and atrial tachycardia) in patients with disabling symptoms after conversion provided that there is definite need for treatment on the basis of severity of clinical symptoms, when other treatment has been ineffective. Structural heart disease and/or impaired left ventricular function should be excluded because of the increased risk for pro-arrhythmic effects.

For this indication, competent medicine agencies globally authorize below treatments:

100-300 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

100 - 300 mg

Dosage regimen

From 50 To 150 mg 2 time(s) per day every day

Detailed description

Initiation of flecainide therapy and dose changes should be made in hospital under ECG and plasma level monitoring. The clinical decision to initiate flecainide treatment should be made in consultation with a specialist. In patients with an underlying organic cardiopathy and especially those with a history of myocardial infarction, flecainide treatment should only be started when other arrhythmic agents, other than class 1C (especially amiodarone), are ineffective or not tolerated and when non-pharmacological treatment (surgery, ablation, implanted defibrillator) is not indicated. Strict medical monitoring of ECG and plasma levels during treatment is required.

Adults and adolescents (13-17 years of age)

Supraventricular arrhythmias: The recommended starting dose is 50mg twice daily and most patients will be controlled at this dose. If required the dose may be increased to a maximum of 300mg daily.

Dosage considerations

In order to avoid the possibility of food affecting the absorption of the drug, flecainide should be taken on an empty stomach or one hour before food.

100-300 mg once daily

Route of admnistration

Oral

Defined daily dose

100 - 300 mg

Dosage regimen

From 100 To 300 mg once every day

Dosage considerations

In order to avoid the possibility of food affecting the absorption of the drug, flecainide should be taken on an empty stomach or one hour before food.

Active ingredient

Flecainide

Flecainide acetate is a Class IC antiarrhythmic agent used for the treatment of severe symptomatic life-threatening ventricular arrhythmias and supraventricular arrhythmias. Electrophysiologically, flecainide is a local anaesthetic-type (Class IC) of antiarrhythmic compound. It is an amide type of local anaesthetic, being structurally related to procainamide and encainide in so far as these agents are also benzamide derivatives.

Read more about Flecainide

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