Active Ingredient: Iron sucrose
Iron sucrose is indicated for the treatment of iron deficiency in the following indications:
The diagnosis of iron deficiency must be based on appropriate laboratory tests (e.g. Hb, serum ferritin, TSAT, serum iron, etc.).
(Hb haemoglobin, TSAT transferrin saturation)
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
650 - 2,450 mg
From 650 To 2,450 mg once every 2 day(s)
The cumulative dose of iron sucrose must be calculated for each patient individually and must not be exceeded.
The total cumulative dose of iron sucrose, equivalent to the total iron deficit (mg), is determined by the haemoglobin level (Hb) and body weight (BW). The dose of iron sucrose must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example:
Total iron deficit [mg] = BW [kg] x (target Hb – actual Hb) [g/dl] x 2.4* + storage iron [mg]
* Factor 2.4 = 0.0034 (iron content of Hb = 0.34%) x 0.07 (blood volume = 7% of BW) x 1000 (conversion of [g] to [mg]) x 10
Total iron sucrose to be administered (in ml) = Total iron deficit [mg] / 20 mg iron/ml
Total amount of iron sucrose (ml) to be administered according to body weight, actual Hb level and target Hb level*:
| BW | Total amount of iron sucrose (20 mg iron per ml) to be administered | |||
|---|---|---|---|---|
| Hb 6.0 g/dl | Hb 7.5 g/dl | Hb 9.0 g/dl | Hb 10.5 g/dl | |
| 30 kg | 47.5 ml | 42.5 ml | 37.5 ml | 32.5 ml |
| 35 kg | 62.5 ml | 57.5 ml | 50 ml | 45 ml |
| 40 kg | 67.5 ml | 60 ml | 55 ml | 47.5 ml |
| 45 kg | 75 ml | 65 ml | 57.5 ml | 50 ml |
| 50 kg | 80 ml | 70 ml | 60 ml | 52.5 ml |
| 55 kg | 85 ml | 75 ml | 65 ml | 55 ml |
| 60 kg | 90 ml | 80 ml | 67.5 ml | 57.5 ml |
| 65 kg | 95 ml | 82.5 ml | 72.5 ml | 60 ml |
| 70 kg | 100 ml | 87.5 ml | 75 ml | 62.5 ml |
| 75 kg | 105 ml | 92.5 ml | 80 ml | 65 ml |
| 80 kg | 112.5 ml | 97.5 ml | 82.5 ml | 67.5 ml |
| 85 kg | 117.5 ml | 102.5 ml | 85 ml | 70 ml |
| 90 kg | 122.5 ml | 107.5 ml | 90 ml | 72.5 ml |
* Below 35 kg BW: Target Hb = 13 g/dl
35 kg BW and above: Target Hb = 15 g/dl
To convert Hb (mM) to Hb (g/dl), multiply the former by 1.6.
If the total necessary dose exceeds the maximum allowed single dose, then the administration must be divided.
Iron sucrose may be administered by slow intravenous injection at a rate of 1 ml undiluted solution per minute and not exceeding 10 ml iron sucrose (200 mg iron) per injection.
Iron sucrose may be administered during a haemodialysis session directly into the venous line of the dialysis machine under the same conditions as for intravenous injection.
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