Prophylaxis of migraine

Active Ingredient: Eptinezumab

Indication for Eptinezumab

Population group: only adults (18 years old or older)
Therapeutic intent: Preventive action

Eptinezumab is indicated for the prophylaxis of migraine in adults who have at least 4 migraine days per month.

For this indication, competent medicine agencies globally authorize below treatments:

100-300 mg once every 12 weeks

Route of admnistration

Intravenous

Defined daily dose

100 - 300 mg

Dosage regimen

From 100 To 300 mg once every 84 day(s)

Detailed description

The recommended dose is 100 mg administered by intravenous infusion every 12 weeks. Some patients may benefit from a dosage of 300 mg administered by intravenous infusion every 12 weeks.

The need for dose escalation should be assessed within 12 weeks after initiation of the treatment. When switching dosage, the first dose of the new regimen should be given on the next scheduled dosing date.

Overall benefit and continuation of treatment should be assessed 6 months after initiation of the treatment. Any further decision to continue the treatment should be made on an individual patient basis.

Dosage considerations

Do not administer eptinezumab as a bolus injection.

Active ingredient

Eptinezumab

Eptinezumab is a recombinant humanized immunoglobulin G1 (IgG1) antibody that binds to α- and β-forms of human calcitonin gene-related peptide (CGRP) ligand with low picomolar affinity. Eptinezumab prevents the activation of the CGRP receptors and hence the downstream cascade of physiological events linked to initiation of migraine attacks.

Read more about Eptinezumab

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