Osteoarthritis of the knee

Active Ingredient: Hyaluronate sodium

Indication for Hyaluronate sodium

Population group: only adults (18 years old or older)

For the sustained relief of pain in osteoarthritis of the knee.

For this indication, competent medicine agencies globally authorize below treatments:

20 mg once a week

Route of admnistration


Defined daily dose

20 - 20 mg

Dosage regimen

From 20 To 20 mg once every 7 day(s) for 35 day(s)

Detailed description

20 mg to be injected into the affected joint once a week to a total of five injections, using a standard technique. No adjustment of dose is required in elderly patients.

This can be repeated at not less than 6 monthly intervals.

Dosage considerations

Intra-articular injection of hyaluronate sodium should be made using precise, anatomical localisation into the joint cavity of the knee to be treated. The injection site in the knee is determined by that location which is easier to reach. Usually a lateral approach can be followed, but in some cases a medial approach is preferable. Strict aseptic precautions should be observed during the administration in order to avoid the possibility of developing infections in the injection site. The solution in the pre-filled syringe is ready for use and requires only a sterile disposable needle. To ensure sterility the injection site must be carefully cleansed with antiseptic. Care should be taken to expel any trapped air bubbles from the syringe containing hyaluronate sodium prior to administration.

Joint effusion, if present, should be aspirated by arthrocentesis prior to injection of hyaluronate sodium. The arthrocentesis should be made using a 20 gauge needle and the joint should be aspirated to almost dryness, but not to degree that would compromise the accuracy of the subsequent hyaluronate sodium injection. An appropriate examination of the joint fluid present should be carried out to exclude bacterial infection, prior to injection. The intra-articular injection of hyaluronate sodium can be given using the same needle as used for the arthrocentesis by simply detaching the aspirating syringe and attaching the syringe containing hyaluronate sodium. To make sure the needle is correctly positioned, some synovial fluid should be aspirated prior to the slow injection of hyaluronate sodium. If the patient experiences pain during injection, the procedure may need to be stopped.

For the first 48 hours after the injection, the patient should be advised to rest the treated knee, with as little exercise as possible, avoiding any strenuous or prolonged activity. Subsequently, they may gradually return to their normal level of activity.

Active ingredient

Hyaluronate sodium
Read more about Hyaluronate sodium

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