Carbohydrate depletion, fluid depletion

Active Ingredient: Glucose

Indication for Glucose

Population group: only minors (0 - 18 years old) , adults (18 years old or older)

Glucose 5% is indicated for the treatment of carbohydrate and fluid depletion.

For this indication, competent medicine agencies globally authorize below treatments:

Individual dosing

Route of admnistration


Defined daily dose

1,000 - 3,000 mL

Dosage regimen

From 1,000 To 3,000 mL once every day

Detailed description

The concentration and dosage of glucose 5% intravenous infusion is determined by several factors including the age, weight and clinical condition of the patient. Serum-glucose concentrations may need to be carefully monitored.

Fluid balance, serum glucose, serum sodium and other electrolytes should be monitored before and during administration, especially in patients with increased non-osmotic vasopressin release (syndrome of inappropriate antidiuretic hormone secretion, SIADH) and in patients co-medicated with vasopressin agonist drugs due to the risk of hyponatraemia. Monitoring of serum sodium is particularly important for physiologically hypotonic fluids. Glucose 5% may become extremely hypotonic after administration due to glucose metabolization in the body.

The recommended dosage for treatment of carbohydrate and fluid depletion is:

  • for adults: 500 ml to 3 litres/24h.
  • for babies and children:
    • 0-10 kg body weight: 100 ml/kg/24h.
    • 10-20 kg body weight: 1000 ml + 50 ml/kg over 10 kg/24h.
    • >20 kg body weight: 1500 ml + 20 ml/kg over 20 kg/24h.

The infusion rate depends on the patient’s clinical condition.

Infusion rate should not exceed the patient’s glucose oxidation capacities in order to avoid hyperglycaemia. Therefore, the maximum dose ranges from 5mg/kg/min for adults to 10-18 mg/kg/min for babies and children depending on the age and the total body mass.

The recommended dosage when used as a vehicle or diluent ranges from 50 to 250 ml per dose of medicinal product to be administered.

When glucose 5% is used as a diluent for injectable preparations of other drugs, the dosage and the infusion rate will be principally dictated by the nature and the dose regimen of the prescribed drug.

Active ingredient

Glucose is frequently used in both adults and children to restore blood glucose concentrations in the treatment of hypoglycaemia resulting from insulin excess or from other causes. The metabolism of glucose is an energy source for the body.

Read more about Glucose

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