HIV-1 infection

Active Ingredient: Enfuvirtide

Indication for Enfuvirtide

Population group: only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Enfuvirtide is indicated in combination with other antiretroviral medicinal products for the treatment of HIV-1 infected patients who have received treatment with and failed on regimens containing at least one medicinal product from each of the following antiretroviral classes: protease inhibitors, non-nucleoside reverse transcriptase inhibitors and nucleoside reverse transcriptase inhibitors, or who have intolerance to previous antiretroviral regimens.

For this indication, competent medicine agencies globally authorize below treatments:

180 mg in 2 divided doses daily

Route of admnistration


Defined daily dose

180 - 180 mg

Dosage regimen

From 90 To 90 mg 2 time(s) per day every day

Detailed description

The recommended dose of enfuvirtide is 90 mg twice daily injected subcutaneously into the upper arm, anterior thigh or abdomen.

In case a enfuvirtide dose is missed, patients should be instructed to administer the dose as soon as possible. However, if it is less than 6 hours before the next regular dose, the missed dose should be skipped.

Active ingredient


Enfuvirtide is a member of the therapeutic class called fusion inhibitors. It is an inhibitor of the structural rearrangement of HIV-1 gp41 and functions by specifically binding to this virus protein extracellularly thereby blocking fusion between the viral cell membrane and the target cell membrane, preventing the viral RNA from entering into the target cell.

Read more about Enfuvirtide

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