Bronchospasm

Active Ingredient: Terbutaline

Indication for Terbutaline

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Terbutaline is a selective beta2-adrenergic agonist recommended for the relief of bronchospasm in bronchial asthma and other bronchopulmonary disorders in which bronchospasm or reversible airways obstruction is a complicating factor.

For this indication, competent medicine agencies globally authorize below treatments:

0.5-2 mg daily

For:

Dosage regimens

Respiratory (Inhalation), 0.5 milligrams terbutaline, 1 to 4 times daily. The maximum allowed total dose is 2 milligrams terbutaline daily.

Detailed description

One inhalation (0.5 mg) as required. Not more than 4 inhalations should be required in any 24-hour period.

The duration of action of a single dose is up to 6 hours.

2.5 mg 2-3 times daily

For:

Dosage regimens

Oral, 2.5 milligrams terbutaline, 2 to 3 times daily.

Detailed description

Paediatric population (7-15 years)

The starting dose should normally be 2.5mg (half a tablet) 2 times in 24 hours. However, in some patients, the dose may need to be increased to 2.5mg 3 times in 24 hours.

2.5 mg 3 times daily for 1-2 weeks and thereafter 5 mg 3 times daily

For:

Dosage regimens

Oral, 2.5 milligrams terbutaline, 3 times daily, over the duration of 1 to 2 weeks. Afterwards, oral, 5 milligrams terbutaline, 3 times daily.

Detailed description

During the first 1-2 weeks, 2.5 mg (half a tablet) 3 times in a 24-hour period is recommended. The dose may then be increased to 5 mg (1 tablet) 3 times in a 24-hour period to achieve adequate bronchodilation.

0.25-0.5 mg up to 4 times daily

For:

Dosage regimens

Intravenous, between 0.25 milligrams terbutaline and 0.5 milligrams terbutaline, 1 to 4 times daily.

Detailed description

When a rapid therapeutic response is required, terbutaline can be administered by i.v. bolus. When given as an i.v. bolus the injection must be made slowly noting patient response.

0.25-0.5 mg up to four times a day.

0.25-0.5 mg up to 4 times daily

For:

Dosage regimens

Subcutaneous, between 0.25 milligrams terbutaline and 0.5 milligrams terbutaline, 1 to 4 times daily.

Detailed description

When a rapid therapeutic response is required, terbutaline can be administered by subcutaneous route.

0.25-0.5 mg up to four times a day.

0.25-0.5 mg up to 4 times daily

For:

Dosage regimens

Intramuscular, between 0.25 milligrams terbutaline and 0.5 milligrams terbutaline, 1 to 4 times daily.

Detailed description

When a rapid therapeutic response is required, terbutaline can be administered by intramuscular route.

0.25-0.5 mg up to four times a day.

0.01 mg/kg body weight once

For:

Dosage regimens

Intravenous, 0.01 milligrams terbutaline per kilogram of body weight, one dose.

Detailed description

When a rapid therapeutic response is required, terbutaline can be administered by i.v. bolus. When given as an i.v. bolus the injection must be made slowly noting patient response.

Children 2-15 years: 0.01 mg/kg body weight to a maximum of 0.3 mg total.

AgeAverage weightmg
kg(lb)terbutaline
<310(22)0.1
315(33)0.15
620(44)0.2
825(55)0.25
10+30+(66+)0.3

0.01 mg/kg body weight once

For:

Dosage regimens

Subcutaneous, 0.01 milligrams terbutaline per kilogram of body weight, one dose.

Detailed description

When a rapid therapeutic response is required, terbutaline can be administered by subcutaneous route.

Children 2-15 years: 0.01 mg/kg body weight to a maximum of 0.3 mg total.

AgeAverage weightmg
kg(lb)terbutaline
<310(22)0.1
315(33)0.15
620(44)0.2
825(55)0.25
10+30+(66+)0.3

0.01 mg/kg body weight once

For:

Dosage regimens

Intramuscular, 0.01 milligrams terbutaline per kilogram of body weight, one dose.

Detailed description

When a rapid therapeutic response is required, terbutaline can be administered by intramuscular route.

Children 2-15 years: 0.01 mg/kg body weight to a maximum of 0.3 mg total.

AgeAverage weightmg
kg(lb)terbutaline
<310(22)0.1
315(33)0.15
620(44)0.2
825(55)0.25
10+30+(66+)0.3

Active ingredient

Terbutaline

Terbutaline is a selective beta2-adrenoceptor agonist, thus producing relaxation of bronchial smooth muscle, inhibition of the release of endogenous spasmogens, inhibitions of oedema caused by endogenous mediators, increased mucociliary clearance and relaxation of the uterine muscle.

Read more about Terbutaline

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