Hypertension

Active Ingredient: Aprocitentan

Indication for Aprocitentan

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Aprocitentan, in combination with other antihypertensive drugs, is indicated for the treatment of hypertension, to lower blood pressure (BP) in adult patients who are not adequately controlled on other drugs. Lowering BP reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. There are no controlled trials demonstrating reduction of risk of these events with aprocitentan.

For this indication, competent medicine agencies globally authorize below treatments:

12.5 mg once daily

For:

Dosage regimens

Oral, 12.5 milligrams aprocitentan, once daily.

Detailed description

The recommended dosage is 12.5 mg orally once daily.

If a dose is missed, skip the missed dose and take the next dose at the regular time. Do not take two doses on the same day.

Dosage considerations

Aprocitentan may be taken with or without food.

Active ingredient

Aprocitentan

Aprocitentan is an ERA that inhibits the binding of endothelin (ET)-1 to ETA and ETB receptors. ET-1, via its receptors (ETA and ETB), mediates a variety of deleterious effects such as vasoconstriction, fibrosis, cell proliferation, and inflammation. In hypertension, ET-1 can cause endothelial dysfunction, vascular hypertrophy and remodeling, sympathetic activation, and increased aldosterone synthesis.

Read more about Aprocitentan

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