Treatment of patients with pulmonary arterial hypertension (PAH) classified as WHO functional class III, to improve exercise capacity. Efficacy has been shown in primary pulmonary hypertension and in pulmonary hypertension associated with connective tissue disease.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
100 - 100 mg
From 100 To 100 mg once every day
Sitaxentan is to be taken orally as a dose of 100 mg once daily. It may be taken with or without food and without regard to the time of day.
In the case of clinical deterioration despite sitaxentan treatment for at least 12 weeks, alternative therapies should be considered. However, a number of patients who showed no response by week 12 of treatment with sitaxentan responded favourably by week 24, so an additional 12 weeks of treatment may be considered.
Higher doses did not confer additional benefit sufficient to offset the increased risk of adverse reactions, particularly liver injury.
There is limited experience with abrupt discontinuation of sitaxentan sodium. No evidence for acute rebound has been observed.
It may be taken with or without food and without regard to the time of day.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.