Diabetes mellitus type 2

Active Ingredient: Saxagliptin

Indication for Saxagliptin

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Saxagliptin is indicated in adult patients with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control:

  • as monotherapy when metformin is inappropriate due to intolerance or contraindications
  • in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control.

For this indication, competent medicine agencies globally authorize below treatments:

5 mg once daily

For:

Dosage regimens

Oral, 5 milligrams saxagliptin, once daily.

Detailed description

The recommended dose of saxagliptin is 5 mg once daily. When saxagliptin is used in combination with insulin or a sulphonylurea, a lower dose of the insulin or sulphonylurea may be required to reduce the risk of hypoglycaemia.

The safety and efficacy of saxagliptin as triple oral therapy in combination with metformin and a thiazolidinedione have not been established.

If a dose is missed, it should be taken as soon as the patient remembers. A double dose should not be taken on the same day.

Dosage considerations

It can be taken with or without a meal at any time of the day.

Active ingredient

Saxagliptin

Saxagliptin is a highly potent (Ki: 1.3 nM), selective, reversible, competitive, DPP4 inhibitor. Saxagliptin improves glycaemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes.

Read more about Saxagliptin

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