Diabetes mellitus type 2

Indication for Saxagliptin

Population group: Suitable for both men and women, only adults (18 years old or older)

Saxagliptin is indicated in adult patients with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control:

  • as monotherapy when metformin is inappropriate due to intolerance or contraindications
  • in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control.

For this indication, competent medicine agencies globally authorize below treatments:

5 mg once a day

Route of admnistration

Oral

Defined daily dose

5 - 5 mg

Dosage regimen

From 5 To 5 mg once every day

Detailed description

The recommended dose of saxagliptin is 5 mg once daily. When saxagliptin is used in combination with insulin or a sulphonylurea, a lower dose of the insulin or sulphonylurea may be required to reduce the risk of hypoglycaemia.

The safety and efficacy of saxagliptin as triple oral therapy in combination with metformin and a thiazolidinedione have not been established.

Dosage considerations

It can be taken with or without a meal at any time of the day.

Active ingredient

Saxagliptin is a highly potent (Ki: 1.3 nM), selective, reversible, competitive, DPP4 inhibitor. Saxagliptin improves glycaemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes.

Read more about Saxagliptin

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