Active Ingredient: Sargramostim
Sargramostim is indicated in adult patients with cancer undergoing autologous hematopoietic stem cell transplantation for the mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 250 micrograms sargramostim per square meter of body surface, once daily.
The recommended dose is 250 mcg/m²/day administered intravenously over 24 hours. Continue at the same dose through the period of PBPC collection. The optimal schedule for PBPC collection has not been established. In clinical studies, collection of PBPC was usually begun after 5 days of sargramostim and performed daily until protocol specified targets were achieved.
If WBC greater than 50,000 cells/mm³, reduce the sargramostim dose by 50%. Consider other mobilization therapy if adequate numbers of progenitor cells are not collected.
For:
Subcutaneous, 250 micrograms sargramostim per square meter of body surface, once daily.
The recommended dose is 250 mcg/m²/day administered subcutaneously once daily. Continue at the same dose through the period of PBPC collection. The optimal schedule for PBPC collection has not been established. In clinical studies, collection of PBPC was usually begun after 5 days of sargramostim and performed daily until protocol specified targets were achieved.
If WBC greater than 50,000 cells/mm³, reduce the sargramostim dose by 50%. Consider other mobilization therapy if adequate numbers of progenitor cells are not collected.
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