Active Ingredient: Doravirine
Doravirine is indicated, in combination with other antiretroviral medicinal products, for the treatment of adults, and adolescents aged 12 years and older weighing at least 35 kg infected with human immunodeficiency virus type 1 (HIV-1) without past or present evidence of resistance to the non-nucleoside reverse transcriptase inhibitors (NNRTI) class.
For this indication, competent medicine agencies globally authorize below treatments:
For:
In case that patient weight is ≥ 35 kg, oral, 100 milligrams doravirine, once daily.
The recommended dose is 100 mg taken orally once daily with or without food.
If doravirine is co-administered with rifabutin, one 100 mg tablet of doravirine should be taken twice daily (approximately 12 hours apart).
Co-administration of doravirine with other moderate CYP3A inducers has not been evaluated, but decreased doravirine concentrations are expected. If co-administration with other moderate CYP3A inducers (e.g. dabrafenib, lesinurad, bosentan, thioridazine, nafcillin, modafinil, telotristat ethyl) cannot be avoided, one 100 mg tablet of doravirine should be taken twice daily (approximately 12 hours apart).
If the patient misses a dose of doravirine within 12 hours of the time it is usually taken, the patient should take as soon as possible and resume the normal dosing schedule. If a patient misses a dose by more than 12 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time. The patient should not take 2 doses at one time.
Doravirine must be taken orally, once daily with or without food.
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