Overactive bladder

Indication for Trospium

Population group: Suitable for both men and women, only adults (18 years old or older)

Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in patients with overactive bladder (e.g. idiopathic or neurologic detrusor overactivity).

For this indication, competent medicine agencies globally authorize below treatments:

40 mg in 2 divided doses daily

Route of admnistration


Defined daily dose

40 - 40 mg

Dosage regimen

From 20 To 20 mg 2 time(s) per day every day

Detailed description

20 mg twice daily (40 mg of trospium chloride per day).

The need for continued treatment should be reassessed at regular intervals of 3-6 months.

Patients with renal impairment: In patients with severe renal impairment (creatinine clearance between 10 and 30 ml/min.1.73 m²), the recommended dosage is 20 mg per day or every second day.

Active ingredient

Trospium is an antispasmodic, antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Receptor assays showed that trospium has negligible affinity for nicotinic receptors as compared to muscarinic receptors at concentrations obtained from therapeutic doses. Trospium antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder.

Read more about Trospium

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