Active Ingredient: Ruxolitinib
Ruxolitinib is indicated for the treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Topical, 1 spreads ruxolitinib, 2 times daily.
The recommended dose is a thin layer of cream applied twice daily to the depigmented skin areas up to a maximum of 10% of body surface area (BSA), with a minimum of 8 hours between two applications of ruxolitinib cream. 10% BSA represents an area as large as 10 times the palm of one hand with the 5 fingers. Ruxolitinib cream should be used at the smallest skin area necessary.
No more than two tubes of 100 grams a month should be used.
Satisfactory repigmentation may require treatment beyond 24 weeks. If there is less than 25% repigmentation in treated areas at week 52, treatment discontinuation should be considered.
Once satisfactory repigmentation is achieved, treatment in those areas can be stopped. If depigmentation recurs after treatment discontinuation, therapy can be reinitiated on the affected areas.
There is no need to consider tapering therapy.
The use of ruxolitinib cream in combination with other topical medicinal products used to treat vitiligo has not been evaluated and co-application on the same skin areas is not recommended.
Other topical medicinal products used to treat other conditions on the same skin areas should be applied with a minimum of 2 hours after the application of ruxolitinib cream. This is also applicable to the use of sunscreen or emollients.
Avoid washing treated skin for at least 2 hours after application of ruxolitinib cream.
The cream should not be applied to the lips to avoid its ingestion.
Patients should be instructed to wash their hands after applying the cream, unless it is their hands that are being treated. If someone else applies the cream to the patient, they should wash their hands after application.
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