Acromegaly

Active Ingredient: Octreotide

Indication for Octreotide

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

0.15-1.50 mg in 3 divided doses daily

Route of admnistration

Subcutaneous

Defined daily dose

0.15 - 1.5 mg

Dosage regimen

From 0.05 To 0.5 mg 3 time(s) per day every day

Loading dose

0.15 mg

Detailed description

Initially 0.05 to 0.1 mg by subcutaneous (s.c.) injection every 8 or 12 hours. Dosage adjustment should be based on monthly assessment of GH and IGF-1 levels (target: GH <2.5 ng/mL; IGF-1 within normal range) and clinical symptoms, and on tolerability. In most patients, the optimal daily dose will be 0.3 mg. A maximum dose of 1.5 mg per day should not be exceeded. For patients on a stable dose of octreotide, assessment of GH and IGF-1 should be made every 6 months.

If no relevant reduction in GH levels and no improvement in clinical symptoms have been achieved within 3 months of starting treatment with octreotide, therapy should be discontinued.

Active ingredient

Octreotide

Octreotide is a synthetic octapeptide derivative of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolonged duration of action. It inhibits pathologically increased secretion of growth hormone (GH) and of peptides and serotonin produced within the GEP endocrine system.

Read more about Octreotide

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