Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in adult patients with unstable bladder.
For this indication, competent medicine agencies globally authorize below treatments:
For: Adults (18-64) Elders (65+)
Oral
5 - 20 mg
From 5 To 20 mg once every day
5 mg
10 mg
Starting dose: the recommended starting dose is one 5 mg tablet once daily.
Maintenance dose/dose adjustment: In order to achieve a maintenance dose giving an optimal balance of efficacy and tolerability, after at least one week on 5 mg daily, the dose may be increased to 10 mg once daily, with subsequent incremental increases or decreases of 5 mg/day. There should be an interval of at least one week between dose changes.
Maximum dose: in patients requiring a higher dose, the total daily dose should not exceed 20 mg.
For patients currently taking oxybutynin immediate release, clinical judgement should be exercised in selecting the appropriate dose of oxybutynin. The dosage should be adjusted to the minimum dose that achieves an optimal balance of efficacy and tolerability, taking into account the current immediate-release dose.
In case of a missed dose, the patient should wait and take the next dose at the regular time.
Oxybutinin tablet must be swallowed whole with the aid of liquid, and must not be chewed, divided, or crushed because it is formulated to provide prolonged release.
Oxybutinin tablet may be administered with or without food.
Transdermal
3.9 - 3.9 mg
From 3.9 To 3.9 mg once every 3 day(s)
The recommended dose is one 3.9 mg transdermal patch applied twice weekly (every 3 to 4 days).
Based on clinical trial experience no dose adjustment is considered necessary in this population. Nonetheless oxybutynin transdermal patch should be used with caution in elderly patients, who may be more sensitive to the effects of centrally acting anticholinergics and exhibit differences in pharmacokinetics.
The patch should be applied to dry, intact skin on the abdomen, hip, or buttock immediately after removal from the protective sachet. A new application site should be selected with each new patch to avoid reapplication to the same site within 7 days.
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