Active Ingredient: Durvalumab
Durvalumab in combination with etoposide and either carboplatin or cisplatin is indicated for the first-line treatment of adults with extensive-stage small cell lung cancer (ES-SCLC).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A, in case that patient weight is > 30 kg
Intravenous, 1,500 milligrams durvalumab, once every 3 weeks. This step is repeated 4 times. Afterwards, intravenous, 1,500 milligrams durvalumab, once every 4 weeks.
Regimen B, in case that patient weight is ≤ 30 kg
Intravenous, 20 milligrams durvalumab per kilogram of body weight, once every 3 weeks. This step is repeated 4 times. Afterwards, intravenous, 20 milligrams durvalumab per kilogram of body weight, once every 4 weeks.
1,500 mg in combination with chemotherapy every 3 weeks (21 days) for 4 cycles, followed by 1,500 mg every 4 weeks as monotherapy.
ES-SCLC patients with a body weight of 30 kg or less must receive weight-based dosing of durvalumab at 20 mg/kg. In combination with chemotherapy dose every 3 weeks (21 days), followed by 20 mg/kg every 4 weeks as monotherapy until weight increases to greater than 30 kg.
Until disease progression or unacceptable toxicity.
Dose escalation or reduction is not recommended. Treatment withholding or discontinuation may be required based on individual safety and tolerability.
Durvalumab is to be administered as an intravenous infusion solution over 1 hour.
Administer durvalumab prior to chemotherapy on the same day.
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