Growth disturbance due to insufficient secretion of growth hormone (growth hormone deficiency, GHD)

Active Ingredient: Somatropin

Indication for Somatropin

Population group: only minors (0 - 18 years old)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

25-35 ug/kg once daily

For:

Route of admnistration

Subcutaneous

Defined daily dose

25 - 35 ug per kg of body weight

Dosage regimen

From 25 To 35 ug per kg of body weight once every day

Detailed description

Generally a dose of 0.7-1.0 mg/m² body surface area per day is recommended. Even higher doses have been used.

Where childhood onset GHD persists into adolescence, treatment should be continued to achieve full somatic development (e.g. body composition, bone mass). For monitoring, the attainment of a normal peak bone mass defined as a T score > - 1 (i.e. standardized to average adult peak bone mass measured by dual energy X-ray absorptiometry taking into account sex and ethnicity) is one of the therapeutic objectives during the transition period. For guidance on dosing see adult section below.

Dosage considerations

The injection should be given subcutaneously and the site varied to prevent lipoatrophy.

0.7-1.0 mg/m² once daily

For:

Route of admnistration

Subcutaneous

Defined daily dose

0.7 - 1 mg per m² of body surface area (BSA)

Dosage regimen

From 0.7 To 1 mg per m² of body surface area (BSA) once every day

Detailed description

Generally a dose of 0.7-1.0 mg/m² body surface area per day is recommended. Even higher doses have been used.

Where childhood onset GHD persists into adolescence, treatment should be continued to achieve full somatic development (e.g. body composition, bone mass). For monitoring, the attainment of a normal peak bone mass defined as a T score > - 1 (i.e. standardized to average adult peak bone mass measured by dual energy X-ray absorptiometry taking into account sex and ethnicity) is one of the therapeutic objectives during the transition period. For guidance on dosing see adult section below.

Dosage considerations

The injection should be given subcutaneously and the site varied to prevent lipoatrophy.

Active ingredient

Somatropin

Somatropin is a potent metabolic hormone of importance for the metabolism of lipids, carbohydrates and proteins. In children with inadequate endogenous growth hormone, somatropin stimulates linear growth and increases growth rate. In adults, as well as in children, somatropin maintains a normal body composition by increasing nitrogen retention and stimulation of skeletal muscle growth, and by mobilization of body fat.

Read more about Somatropin

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