Leptospirosis

Active Ingredient: Benzylpenicillin

Indication for Benzylpenicillin

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

600-3600 mg in 4-6 divided doses daily

Route of admnistration

Intravenous

Defined daily dose

600 - 3,600 mg

Dosage regimen

From 150 To 900 mg 4 time(s) per day every day

Detailed description

600 to 3,600 mg (1 to 6 mega units) daily, divided into 4 to 6 doses, depending on the indication.

High doses should be administered by intravenous injection or infusion, with intravenous doses in excess of 1.2g (2 mega units) being given slowly, taking at least one minute for each 300 mg (0.5 mega unit) to avoid high levels causing irritation of the central nervous system and/or electrolyte imbalance.

High dosage of benzylpenicillin sodium may result in hypernatraemia and hypokalaemia unless the sodium content is taken into account.

600-3600 mg in 4-6 divided doses daily

Route of admnistration

Intramuscular

Defined daily dose

600 - 3,600 mg

Dosage regimen

From 150 To 900 mg 4 time(s) per day every day

Detailed description

600 to 3,600 mg (1 to 6 mega units) daily, divided into 4 to 6 doses, depending on the indication.

High doses should be administered by intravenous injection or infusion, with intravenous doses in excess of 1.2g (2 mega units) being given slowly, taking at least one minute for each 300 mg (0.5 mega unit) to avoid high levels causing irritation of the central nervous system and/or electrolyte imbalance.

High dosage of benzylpenicillin sodium may result in hypernatraemia and hypokalaemia unless the sodium content is taken into account.

Active ingredient

Benzylpenicillin

Benzylpenicillin is a beta-lactam antibiotic. It is bacteriocidal by inhibiting bacterial cell wall biosynthesis. Penicillin resistance can be mediated by alteration of penicillin binding proteins or development of beta-lactamases.

Read more about Benzylpenicillin

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