Active Ingredient: Serplulimab
Serplulimab in combination with carboplatin and pemetrexed is indicated for the first-line treatment of adult non-squamous NSCLC patients with no EGFR, ALK or ROS1 positive mutations and who have:
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 4.5 milligrams serplulimab per kilogram of body weight, once every 3 weeks.
The recommended dose in both the induction and maintenance phases is 4.5 mg/kg bodyweight serplulimab every 3 weeks until disease progression or unacceptable toxicity. During the induction phase (4 cycles), carboplatin and pemetrexed are administered on day 1 of each 3-week cycle. During the maintenance phase, the administration of pemetrexed is continued at the discretion of the physician.
Dose escalation or reduction of serplulimab is not recommended. Dose withholding or discontinuation may be required based on individual safety and tolerability. Dose withholding for up to 12 weeks for tolerability is acceptable.
No dose adjustment is needed for elderly patients (≥65 years).
When administered in combination with chemotherapy, serplulimab should be given first followed by chemotherapy on the same day. Use separate infusion bags for each infusion.
Serplulimab must not be administered as an intravenous push or bolus injection.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.