Severe hypertriglyceridaemia, mixed hyperlipidaemia

Active Ingredient: Bezafibrate

Indication for Bezafibrate

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Bezafibrate is indicated as an adjunct to diet and other non-pharmacological treatment (e.g. exercise, weight reduction) for the following:

  • Treatment of severe hypertriglyceridaemia with or without low HDL cholesterol.
  • Mixed hyperlipidaemia when a statin is contraindicated or not tolerated.

For this indication, competent medicine agencies globally authorize below treatments:

400-600 mg in 2-3 divided doses daily

Route of admnistration


Defined daily dose

400 - 600 mg

Dosage regimen

From 133.333 To 200 mg 3 time(s) per day every day

Loading dose

400 mg

Detailed description

The recommended dosage is 200 mg bezafibrate taken three times daily. Occasionally gastrointestinal symptoms may occur. In susceptible patients, slowly increasing dosage over 5 to 7 days may help to avoid such symptoms.

Dosage considerations

Bezafibrate should be taken with a sufficient amount of fluid after each meal.

Active ingredient


Bezafibrate lowers elevated blood lipids (triglycerides and cholesterol). Elevated VLDL and LDL are reduced by treatment with bezafibrate, whilst HDL-levels are increased. Furthermore, cholesterol biosynthesis is reduced by bezafibrate, which is accompanied by a stimulation of the LDL receptor-mediated lipoprotein catabolism.

Read more about Bezafibrate

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