Multi-drug resistant tuberculosis

Active Ingredient: 4-Aminosalicylic acid

Indication for 4-Aminosalicylic acid

Population group: only adults (18 years old or older)

4-Aminosalicylic acid is indicated for use as part of an appropriate combination regimen for multi-drug resistant tuberculosis in adults and paediatric patients from 28 days of age and older when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

For this indication, competent medicine agencies globally authorize below treatments:

4 g three times per day

Route of admnistration

Oral

Defined daily dose

12 g

Dosage regimen

4 g 3 time(s) per day every day for 730 day(s)

Detailed description

4 g three times per day. The recommended schedule is 4 g every 8 hours.

Maximum daily dose is 12 g. Usual duration of treatment is 24 months.

Desensitization

Desensitization can be accomplished by starting with 10 mg para-aminosalicylic acid (PAS) given as a single dose. The dosage is doubled every 2 days until reaching a total of 1 gram after which the dosage is divided to follow the regular schedule of administration. If a mild temperature rise or skin reaction develops, the increment is to be dropped back one level or the progression held for one cycle. Reactions are rare after a total dosage of 1.5 g.

Dosage considerations

4-Aminosalicylic acid can be taken with food.

Active ingredient

4-Aminosalicylic acid

Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis. It inhibits the onset of bacterial resistance to streptomycin and isoniazid.

Read more about 4-Aminosalicylic acid

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