Waldenström’s macroglobulinaemia (WM)

Active Ingredient: Ibrutinib

Indication for Ibrutinib

Population group: only adults (18 years old or older)

Ibrutinib as a single agent is indicated for the treatment of adult patients with Waldenström’s macroglobulinaemia (WM) who have received at least one prior therapy, or in first line treatment for patients unsuitable for chemo-immunotherapy. Ibrutinib in combination with rituximab is indicated for the treatment of adult patients with WM.

For this indication, competent medicine agencies globally authorize below treatments:

420 mg once daily

Route of admnistration

Oral

Defined daily dose

420 - 420 mg

Dosage regimen

From 420 To 420 mg once every day

Detailed description

The recommended dose for the treatment of WM is 420 mg once daily.

Active ingredient

Ibrutinib

Ibrutinib is a potent, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK). BTK, a member of the Tec kinase family, is an important signalling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. Preclinical studies have shown that ibrutinib effectively inhibits malignant B-cell proliferation and survival in vivo as well as cell migration and substrate adhesion in vitro.

Read more about Ibrutinib

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