Active Ingredient: Daunorubicin
As an antimitotic and cytotoxic for the induction of remissions in acute lymphocytic and myelogenous leukaemias.
Daunorubicin, as part of combination regimen, is indicated for the treatment of acute lymphocytic leukemia and acute myeloid leukemia in children.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, between 40 milligrams daunorubicin per square meter of body surface and 60 milligrams daunorubicin per square meter of body surface, 1 to 3 doses in total.
40-60mg/m² on alternate days for a course of up to three infusions.
45mg/m²/day is the recommended dose.
Use with care in patients with inadequate bone marrow reserves. A dosage reduction of up to 50% is recommended.
For:
Intravenous, 300 milligrams daunorubicin per square meter of body surface, once every 3 to 6 weeks.
Cerubidin dose for children (over 2 years) is usually calculated based on the body surface area and adjusted to meet individual requirements of each patient, on the basis of clinical response and the patient’s haematological status. Courses may be repeated after 3 to 6 weeks.
Current specialized protocols and guidelines should be consulted for appropriate treatment regimen.
For children over 2 years the maximum cumulative dose is 300 mg/m².
For children under 2 years of age (or below 0.5 m² body surface area), the maximum cumulative dose is 10 mg/kg.
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