Melanoma

Active Ingredient: Ipilimumab

Indication for Ipilimumab

Population group: only adolescents (12 years - 18 years old)

Ipilimumab as monotherapy is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults, and adolescents 12 years of age and older.

For this indication, competent medicine agencies globally authorize below treatments:

3 mg/kg once every 3 week

Route of admnistration

Intravenous

Defined daily dose

3 - 3 mg per kg of body weight

Dosage regimen

From 3 To 3 mg per kg of body weight once every 21 day(s) for 84 day(s)

Detailed description

The recommended induction regimen of ipilimumab is 3 mg/kg administered intravenously over a 90-minute period every 3 weeks for a total of 4 doses. Patients should receive the entire induction regimen (4 doses) as tolerated, regardless of the appearance of new lesions or growth of existing lesions. Assessments of tumour response should be conducted only after completion of induction therapy.

Dosage considerations

The recommended infusion period is 30 or 90 minutes, depending on the dose.

Active ingredient

Ipilimumab

Ipilimumab is a CTLA-4 immune checkpoint inhibitor that blocks T-cell inhibitory signals induced by the CTLA-4 pathway, increasing the number of reactive T-effector cells which mobilize to mount a direct T-cell immune attack against tumour cells.

Read more about Ipilimumab

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