Urothelial carcinoma

Active Ingredient: Atezolizumab

Indication for Atezolizumab

Population group: only adults (18 years old or older)

Atezolizumab as monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma (UC):

after prior platinum-containing chemotherapy, or
who are considered cisplatin ineligible, and whose tumours have a PD-L1 expression ≥5%.

For this indication, competent medicine agencies globally authorize below treatments:

1,200 mg once every 3 weeks

Route of admnistration

Intravenous

Defined daily dose

1,200 mg

Dosage regimen

1,200 mg once every 21 day(s)

Detailed description

The recommended dose of atezolizumab is 1,200 mg administered intravenously every three weeks.

Dosage considerations

The initial dose of atezolizumab must be administered over 60 minutes. If the first infusion is well tolerated, all subsequent infusions may be administered over 30 minutes.

Active ingredient

Atezolizumab
Atezolizumab is an Fc-engineered, humanised immunoglobulin G1 (IgG1) monoclonal antibody that directly binds to PD-L1 and provides a dual blockade of the PD-1 and B7.1 receptors, releasing PD-L1/PD-1 mediated inhibition of the immune response, including reactivating the antitumour immune response without inducing antibody-dependent cellular cytotoxicity. Read more about Atezolizumab

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