Tachyarrhythmias

Active Ingredient: Amiodarone

Indication for Amiodarone

Population group: only adults (18 years old or older)
  • Treatment of severe rhythm disorders not responding to other therapies or when other treatments cannot be used.
  • Tachyarrhythmias associated with Wolff-Parkinson-White Syndrome.
  • Atrial flutter and fibrillation when other drugs cannot be used.
  • All types of tachyarrhythmias of paroxysmal nature including: supraventricular, nodal and ventricular tachycardias, ventricular fibrillation: when other drugs cannot be used.

For this indication, competent medicine agencies globally authorize below treatments:

200-600 mg daily

Route of admnistration

Oral

Defined daily dose

600 mg

Dosage regimen

200 mg 3 time(s) per day every day

Loading dose

600 mg

Maintenance dose

200 mg

Detailed description

Initial Stabilisation

Treatment should be started with 200mg, three times a day and may be continued for 1 week. The dosage should then be reduced to 200mg, twice daily for a further week.

Maintenance

After the initial period the dosage should be reduced to 200mg daily, or less if appropriate. Rarely, the patient may require a higher maintenance dose. The scored 100mg tablet should be used to titrate the minimum dosage required to maintain control of the arrhythmia. The maintenance dose should be regularly reviewed, especially where this exceeds 200mg daily.

300mg over 20 minutes to 2 hours, followed by 900mg over 24 hours

Route of admnistration

Intravenous

Defined daily dose

5 - 15 mg per kg of body weight

Dosage regimen

From 5 To 15 mg per kg of body weight once every day

Loading dose

5 mg per kg of body weight

Detailed description

Loading dose

Usually 300mg in 100mls Glucose 5% over 20 minutes to 2 hours, followed by continuous infusion of 900mg in 500mls Glucose 5% over 24 hours.

If the arrhythmia remains uncontrolled the infusion may be repeated in doses up to 1200mg (approximately 15mg/kg bodyweight) over 24 hours and the rate then adjusted on the basis of clinical response.

Maintenance dose

Only use IV amiodarone for maintenance dose if patient unable to take orally. Repeated infusion is very irritant and continuous infusion should therefore be via a central line.

Active ingredient

Amiodarone

Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia.

Read more about Amiodarone

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