Type 2 diabetes mellitus

Active Ingredient: Linagliptin

Indication for Linagliptin

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct intent

Linagliptin is indicated in adults with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control as:

monotherapy

  • when metformin is inappropriate due to intolerance, or contraindicated due to renal impairment.

combination therapy

  • in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control.

For this indication, competent medicine agencies globally authorize below treatments:

5 mg once daily

For:

Dosage regimens

Oral, 5 milligrams linagliptin, once daily.

Detailed description

The dose of linagliptin is 5 mg once daily. When linagliptin is added to metformin, the dose of metformin should be maintained, and linagliptin administered concomitantly.

When linagliptin is used in combination with a sulphonylurea or with insulin, a lower dose of the sulphonylurea or insulin, may be considered to reduce the risk of hypoglycaemia

Linagliptin can be taken at any time of the day. If a dose is missed, it should be taken as soon as the patient remembers. A double dose should not be taken on the same day.

Active ingredient

Linagliptin

Linagliptin is an inhibitor of the enzyme DPP-4 (dipeptidyl peptidase 4, EC 3.4.14.5) an enzyme which is involved in the inactivation of the incretin hormones GLP-1 and GIP (glucagon-like peptide1, glucose-dependent insulinotropic polypeptide). These hormones are rapidly degraded by the enzyme DPP-4. Both incretin hormones are involved in the physiological regulation of glucose homeostasis.

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