For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
143 [iU] per kg of body weight
71.5 [iU] per kg of body weight 2 time(s) per day every day
A daily dose of 143 IU anti-Xa/kg body weight divided in two subcutaneous injections is recommended for the initial treatment of deep vein thrombosis). The maximum daily dose is 10,307 IU. Oral anticoagulation can be started at the same time with the goal of achieving a PK-INR (International Normalised Ratio) in the therapeutic target range of 2.0–3.0. Clivarin treatment should be given for at least 5-7 days.
In clinical studies the following dose scheme has proven to be effective:
| Bodyweight | Reviparin dose | Volume |
|---|---|---|
| 35-45 kg | 2,863 IU anti-Xa twice daily | 0.50 ml |
| 46-60 kg | 3,436 IU anti-Xa twice daily | 0.60 ml |
| >60 kg | 5,153 IU anti-Xa twice daily | 0.90 ml |
For patients over 60 kg experience is available with the administration of 10,307 IU once daily.