Active Ingredient: Epoetin zeta
Epoetin zeta is indicated in adults in a predonation programme to increase the yield of autologous blood. Treatment should only be given to patients with moderate anaemia (haemoglobin [Hb] concentration range between 10 to 13 g/dL [6.2 to 8.1 mmol/L], no iron deficiency) if blood saving procedures are not available or insufficient when the scheduled major elective surgery requires a large volume of blood (4 or more units of blood for females or 5 or more units for males).
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
600 - 600 [iU] per kg of body weight
From 600 To 600 [iU] per kg of body weight once every 3 day(s)
Mildly anaemic patients (haematocrit of 33 to 39%) requiring predeposit of ≥4 units of blood should be treated with epoetin zeta 600 IU/kg intravenously, 2 times per week for 3 weeks prior to surgery. Epoetin zeta should be administered after the completion of the blood donation procedure.
Administer over at least one to five minutes, depending on the total dose. In haemodialysed patients, a bolus injection may be given during the dialysis session through a suitable venous port in the dialysis line. Alternatively, the injection can be given at the end of the dialysis session via the fistula needle tubing, followed by 10 mL of isotonic saline to rinse the tubing and ensure satisfactory injection of the product into the circulation.
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