Active Ingredient: Baricitinib
Baricitinib is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs. Baricitinib may be used as monotherapy or in combination with methotrexate.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
2 - 4 mg
From 2 To 4 mg once every day
2 mg
The recommended dose of baricitinib is 4 mg once daily. A dose of 2 mg once daily is appropriate for patients such as those aged ≥75 years and may be appropriate for patients with a history of chronic or recurrent infections. A dose of 2 mg once daily may also be considered for patients who have achieved sustained control of disease activity with 4 mg once daily and are eligible for dose tapering.
Treatment should not be initiated in patients with an absolute lymphocyte count (ALC) less than 0.5 × 109 cells/L, an absolute neutrophil count (ANC) less than 1 × 109 cells/L, or who have a haemoglobin value less than 8 g/dL. Treatment may be initiated once values have improved above these limits.
Baricitinib is to be taken once daily with or without food and may be taken at any time of the day.
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