As an alternative intravenous agent for the induction of anaesthesia in high risk and elderly patients, especially where cardiovascular stability is of particular importance. Induction is more reliable when heavy opiate premedication has been administered or when midazolam is given with a narcotic analgesic such as fentanyl.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
0.1 - 0.2 mg per kg of body weight
From 0.1 To 0.2 mg per kg of body weight once every day
Older patients are more sensitive to the effects of benzodiazepines. Induction may be adequate with 0.1mg/kg body-weight in premedicated patients and 0.2mg/kg body-weight in unpremedicated patients. Initial dose should not exceed 1-1.5mg (0.2-0.3ml).
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