Botulinum toxin type A is indicated for the management of severe hyperhidrosis of the axillae, which does not respond to topical treatment with antiperspirants or antihidrotics.
For this indication, competent medicine agencies globally authorize below treatments:
For: Adults (18-64) Elders (65+)
Intradermal, 50 international units, once every 16 weeks.
Recommended needle: Sterile 30 gauge needle.
Administration guidance: The hyperhidrotic area to be injected may be defined by using standard staining techniques, e.g. Minor´s iodine-starch test.
Recommended dose: 50 Units of botulinum toxin type A is injected intradermally to each axilla, evenly distributed in multiple sites approximately 1-2 cm apart.
The recommended injection volume for intradermal injection is 0.1-0.2 ml.
Maximum dose: Doses other than 50 Units per axilla cannot be recommended.
Additional information: Clinical improvement generally occurs within the first week after injection and persists for 4-7 months.
Repeat injection of botulinum toxin type A can be administered when the clinical effect of a previous injection diminishes and the treating physician deems it necessary. Injections should not be repeated more frequently than every 16 weeks.
The maximum cumulative dose should not exceed 400 Units in a 12-week interval.