Active Ingredient: Dienogest

Indication for Dienogest

Population group: women, only adults (18 - 65 years old)
Therapeutic intent: Curative procedure

Treatment of endometriosis.

For this indication, competent medicine agencies globally authorize below treatments:

2 mg once daily


Dosage regimens

Oral, 2 milligrams dienogest, once daily.

Detailed description

The dosage of dienogest is 2 mg daily without any break, taken preferably at the same time each day with some liquid as needed.

Tablets must be taken continuously without regard to vaginal bleeding. When a pack is finished the next one should be started without interruption.

There is no experience with dienogest treatment >15 months in patients with endometriosis. Treatment can be started on any day of the menstrual cycle.

Any hormonal contraception needs to be stopped prior to initiation of dienogest. If contraception is required, non-hormonal methods of contraception should be used (e.g. barrier method).

Management of missed tablets

The efficacy of dienogest may be reduced in the event of missed tablets, vomiting and/or diarrhea (if occuring within 3-4 hours after tablet taking). In the event of one or more missed tablets, the woman should take one tablet only, as soon as she remembers, and should then continue the next day at her usual time. A tablet not absorbed due to vomiting or diarrhea should likewise be replaced by one tablet.

Dosage considerations

The tablet can be taken with or without food.

Active ingredient


Dienogest is a nortestosterone derivative with no androgenic but rather an antiandrogenic activity of approximately one third of that of cyproterone acetate. Dienogest binds to the progesterone receptor of the human uterus with only 10% of the relative affinity of progesterone.

Read more about Dienogest

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