Prevention of skeletal related events

Active Ingredient: Zoledronic acid

Indication for Zoledronic acid

Population group: only adults (18 years old or older)
Therapeutic intent: Preventive action

Prevention of skeletal related events (pathological fractures, spinal compression, radiation or surgery to bone, or tumour-induced hypercalcaemia) in adult patients with advanced malignancies involving bone.

For this indication, competent medicine agencies globally authorize below treatments:

4 mg every 3-4 weeks


Dosage regimens

Intravenous, 4 milligrams zoledronic acid, once every 3 to 4 weeks.

Detailed description

The recommended dose in the prevention of skeletal related events in patients with advanced malignancies involving bone is 4 mg zoledronic acid every 3 to 4 weeks.

Patients should also be administered an oral calcium supplement of 500 mg and 400 IU vitamin D daily.

The decision to treat patients with bone metastases for the prevention of skeletal related events should consider that the onset of treatment effect is 2-3 months.

Dosage considerations

Zoledronic acid solution should be given as a single intravenous infusion in no less than 15 minutes.

Active ingredient

Zoledronic acid

Zoledronic acid belongs to the class of bisphosphonates and acts primarily on bone. It is an inhibitor of osteoclastic bone resorption.

Read more about Zoledronic acid

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