Alleviation of symptoms of salivary gland hypofunction in patients with severe xerostomia following irradiation for head and neck cancer.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
15 - 30 mg
From 5 To 10 mg 3 time(s) per day every day
The recommended initial dose for adults is 5 mg three times daily. The maximal therapeutic effect is normally obtained after 4 to 8 weeks of therapy. For patients who have not responded sufficiently after 4 weeks and who tolerate the dose of 5 mg three times daily, doses of up to a maximum of 30 mg daily may be considered. However, higher daily doses are probably accompanied by an increase in drug-related adverse effects. Therapy should be discontinued if no improvement in xerostomia is noted after 2 to 3 months of therapy.
It should be taken during or directly after meals. The last tablet should always be taken in conjunction with the evening meal.