Zollinger-Ellison syndrome

Active Ingredient: Ranitidine

Indication for Ranitidine

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

150-6000 mg in divided doses daily

Route of admnistration

Oral

Defined daily dose

450 - 6,000 mg

Dosage regimen

From 150 To 2,000 mg 3 time(s) per day every day

Detailed description

The starting dose for Zollinger-Ellison syndrome is 150 mg three times daily, and this may be increased as necessary. Doses up to 6 grams per day have been well tolerated.

150-200 mg in 3-4 divided doses daily

Route of admnistration

Intravenous

Defined daily dose

150 - 200 mg

Dosage regimen

From 37.5 To 50 mg 4 time(s) per day every day

Detailed description

Ranitidine may be given either as a slow (over 2 minutes) intravenous injection up to a maximum of 50 mg, after dilution to a volume of 20 ml per 50 mg dose, which may be repeated every 6 to 8 hours; or as an intermittent intravenous infusion at a rate of 25 mg per hour for two hours; the infusion may be repeated at 6 to 8 hour intervals.

150-200 mg in 3-4 divided doses daily

Route of admnistration

Intramuscular

Defined daily dose

150 - 200 mg

Dosage regimen

From 37.5 To 50 mg 4 time(s) per day every day

Detailed description

Ranitidine may be given either as a slow (over 2 minutes) intravenous injection up to a maximum of 50 mg, after dilution to a volume of 20 ml per 50 mg dose, which may be repeated every 6 to 8 hours; or as an intermittent intravenous infusion at a rate of 25 mg per hour for two hours; the infusion may be repeated at 6 to 8 hour intervals, or as an intramuscular injection of 50 mg (2 ml) every 6 to 8 hours.

Active ingredient

Ranitidine

Ranitidine is a specific rapidly acting histamine H2-antagonist. It inhibits basal and stimulated secretion of gastric acid, reducing both the volume and the acid and pepsin content of the secretion. Ranitidine has a relatively long duration of action and so a single 150 mg dose effectively suppresses gastric acid secretion for twelve hours.

Read more about Ranitidine

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