Headache phase of migraine attacks with or without aura

Active Ingredient: Rizatriptan

Indication for Rizatriptan

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Acute treatment of the headache phase of migraine attacks with or without aura in adults.

For this indication, competent medicine agencies globally authorize below treatments:

10-20 mg in 1-2 divided doses

Route of admnistration

Oral

Defined daily dose

10 - 20 mg

Dosage regimen

From 5 To 10 mg 2 time(s) per day every day

Detailed description

The recommended dose is 10 mg.

Redosing: Doses should be separated by at least two hours; no more than two doses should be taken in any 24-hour period.

For headache recurrence within 24 hours: If headache returns after relief of the initial attack, one further dose may be taken. The above dosing limits should be observed.

After non-response: The effectiveness of a second dose for treatment of the same attack, when an initial dose is ineffective, has not been examined in controlled trials. Therefore, if a patient does not respond to the first dose, a second dose should not be taken for the same attack.

Dosage considerations

Rizatriptan should not be used prophylactically.

The oral tablets should be swallowed whole with liquid.

Effect of Food

The absorption of rizatriptan is delayed by approximately 1 hour when administered together with food. Therefore, onset of effect may be delayed when rizatriptan is administered in the fed state.

Active ingredient

Rizatriptan

Rizatriptan binds selectively with high affinity to human 5-HT1B and 5-HT1D receptors. The therapeutic activity of rizatriptan in treating migraine headache may be attributed to its agonist effects at 5-HT1B and 5-HT1D receptors on the extracerebral intracranial blood vessels that are thought to become dilated during an attack and on the trigeminal sensory nerves that innervate them.

Read more about Rizatriptan

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