Active Ingredient: Propofol
Propofol is a short-acting intravenous general anaesthetic for sedation for diagnostic and surgical procedures, alone or in combination with local or regional anaesthesia in adults and children over one month of age.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, between 0.5 milligrams propofol per kilogram of body weight and 1 milligrams propofol per kilogram of body weight, over the duration of 1 to 5 minutes. Afterwards, intravenous, between 1.5 milligrams propofol per kilogram of body weight and 4.5 milligrams propofol per kilogram of body weight, over the duration of 1 hour.
To provide sedation for surgical and diagnostic procedures rates of administration should be individualised and titrated to clinical response.
Most patients will require 0.5 to 1 mg/kg over 1 to 5 minutes to initiate sedation.
Maintenance of sedation may be accomplished by titrating Diprivan infusion to the desired level of sedation – most patients will require 1.5 to 4.5 mg/kg/h. In addition to the infusion, bolus administration of 10 to 20 mg may be used if a rapid increase in the depth of sedation is required. In patients of ASA grades 3 and 4 the rate of administration and dosage may need to be reduced.
Where propofol is used for maintenance of sedation the rate of infusion or 'target concentration' should also be reduced. Patients of ASA grades 3 and 4 will require further reductions in dose and dose rate. Rapid bolus administration (single or repeated) should not be used in older people as this may lead to cardiorespiratory depression.
For:
In the case that patient age in months is ≥ 1 :
Intravenous, between 1 milligrams propofol per kilogram of body weight and 2 milligrams propofol per kilogram of body weight, one dose. Afterwards, intravenous, between 1.5 milligrams propofol per kilogram of body weight and 9 milligrams propofol per kilogram of body weight, over the duration of 1 day.
Propofol is not recommended for surgical and diagnostic procedures in children aged less than 1 month.
In children over 1 month of age, doses and administration rates should be adjusted according to the required depth of sedation and the clinical response. Most paediatric patients require 1–2 mg/kg body weight of propofol 1% for onset of sedation. Maintenance of sedation may be accomplished by titrating propofol 1% infusion to the desired level of sedation. Most patients require 1.5–9 mg/kg/h propofol 1%. The infusion may be supplemented by bolus administration of up to 1 mg/kg body weight if a rapid increase of depth of sedation is required.
In ASA 3 and 4 patients lower doses may be required.
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