Reversal of sedation

Active Ingredient: Flumazenil

Indication for Flumazenil

Population group: only adults (18 years old or older)

Flumazenil is indicated for the complete or partial reversal of the central sedative effects of benzodiazepines. It may therefore be used in anaesthesia in the following situations:

  • Termination of hypnosedative effects in general anaesthesia induced and/or maintained with benzodiazepines in hospitalised patients.
  • Reversal of benzodiazepine sedation in short-term diagnostic and therapeutic procedures in ambulatory patients and hospitalised patients.

For this indication, competent medicine agencies globally authorize below treatments:

0.2-1.0 mg in 1-8 divided doses

Route of admnistration

Intravenous

Defined daily dose

0.2 - 1 mg

Dosage regimen

From 0.05 To 0.25 mg 4 time(s) per day every day

Detailed description

The recommended starting dose is 200 micrograms administered intravenously over 15 seconds. If the required level of consciousness is not obtained within 60 seconds, a further dose of 100 micrograms can be injected and repeated at 60-second intervals, up to a maximum dose of 1000 micrograms. The usual dose is 300 to 600 micrograms, but may deviate depending on the patient’s characteristics and the benzodiazepine used.

Active ingredient

Flumazenil

Flumazenil, an imidazobenzodiazepine, is a benzodiazepine antagonist which, by competitive interaction, blocks the effects of substances acting via the benzodiazepine-receptor. Neutralisation of paradoxal reactions of benzodiazepines has been reported.

Read more about Flumazenil

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