Flumazenil is indicated for the complete or partial reversal of the central sedative effects of benzodiazepines. It may therefore be used in anaesthesia in the following situations:
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
0.2 - 1 mg
From 0.05 To 0.25 mg 4 time(s) per day every day
The recommended starting dose is 200 micrograms administered intravenously over 15 seconds. If the required level of consciousness is not obtained within 60 seconds, a further dose of 100 micrograms can be injected and repeated at 60-second intervals, up to a maximum dose of 1000 micrograms. The usual dose is 300 to 600 micrograms, but may deviate depending on the patient’s characteristics and the benzodiazepine used.
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