Metastatic colorectal cancer (mCRC)

Active Ingredient: Ramucirumab

Indication for Ramucirumab

Population group: only adults (18 years old or older)

Ramucirumab, in combination with FOLFIRI (irinotecan, folinic acid, and 5-fluorouracil), is indicated for the treatment of adult patients with metastatic colorectal cancer (mCRC) with disease progression on or after prior therapy with bevacizumab, oxaliplatin and a fluoropyrimidine.

For this indication, competent medicine agencies globally authorize below treatments:

8 mg/kg once every 2 weeks

Route of admnistration

Intravenous

Defined daily dose

8 - 8 mg per kg of body weight

Dosage regimen

From 8 To 8 mg per kg of body weight once every 15 day(s)

Detailed description

The recommended dose of ramucirumab is 8 mg/kg every 2 weeks administered by intravenous infusion, prior to FOLFIRI administration. Prior to chemotherapy, patients should have a complete blood count. Criteria to be met prior to FOLFIRI are provided in the following table.

Criteria to be met prior to FOLFIRI administration:

 Criteria
Neutrophils≥1.5 × 109/l
Platelets≥100 × 109/l
Chemotherapy-related gastro-intestinal toxicity≤ Grade 1 (National Cancer Institute Common Terminology Criteria for Adverse Events [NCI CTCAE])

Active ingredient

Ramucirumab

Ramucirumab is a human receptor-targeted antibody that specifically binds VEGF Receptor 2 and blocks binding of VEGF-A, VEGF-C, and VEGF-D. Vascular Endothelial Growth Factor (VEGF) Receptor 2 is the key mediator of VEGF induced angiogenesis. As a result, ramucirumab inhibits ligand stimulated activation of VEGF Receptor 2 and its downstream signalling components, including p44/p42 mitogen-activated protein kinases, neutralising ligand-induced proliferation and migration of human endothelial cells.

Read more about Ramucirumab

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