Active Ingredient: Tafamidis
Tafamidis is indicated for the treatment of wild-type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy (ATTR-CM).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 61 milligrams tafamidis, once daily.
The recommended dose is 61 mg of tafamidis orally once daily.
61 mg tafamidis corresponds to 80 mg tafamidis meglumine. Tafamidis and tafamidis meglumine are not interchangeable on a per mg basis.
Tafamidis should be started as early as possible in the disease course when the clinical benefit on disease progression could be more evident. Conversely, when amyloid-related cardiac damage is more advanced, such as in NYHA Class III, the decision to start or maintain treatment should be taken at the discretion of a physician knowledgeable in the management of patients with amyloidosis or cardiomyopathy. There are limited clinical data in patients with NYHA Class IV.
If vomiting occurs after dosing, and the intact tafamidis capsule is identified, then an additional dose of tafamidis should be administered if possible. If no capsule is identified, then no additional dose is necessary, with resumption of dosing the next day as usual.
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