Active Ingredient: Liraglutide
Liraglutide is indicated for the treatment of adults, adolescents and children aged 10 years and above with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous, 0.6 milligrams liraglutide, once daily, over the duration of 1 week. Afterwards, subcutaneous, 1.2 milligrams liraglutide, once daily, over the duration of 1 week. Afterwards, subcutaneous, between 1.2 milligrams liraglutide and 1.8 milligrams liraglutide, once daily. The maximum allowed total dose is 1.8 milligrams liraglutide daily.
To improve gastro-intestinal tolerability, the starting dose is 0.6 mg liraglutide daily. After at least one week, the dose should be increased to 1.2 mg. Some patients are expected to benefit from an increase in dose from 1.2 mg to 1.8 mg and based on clinical response, after at least one week, the dose can be increased to 1.8 mg to further improve glycaemic control. Daily doses higher than 1.8 mg are not recommended.
When liraglutide is added to a sulfonylurea or insulin, a reduction in the dose of sulfonylurea or insulin should be considered to reduce the risk of hypoglycaemia. Combination therapy with sulfonylurea is only valid for adult patients.
Self-monitoring of blood glucose is not needed in order to adjust the dose of liraglutide. Blood glucose self-monitoring is necessary to adjust the dose of sulfonylurea and insulin, particularly when liraglutide therapy is started and insulin is reduced. A stepwise approach to insulin dose reduction is recommended.
Liraglutide is administered once daily at any time, independent of meals, and can be injected subcutaneously in the abdomen, in the thigh or in the upper arm. The injection site and timing can be changed without dose adjustment. However, it is preferable that liraglutide is injected around the same time of the day, when the most convenient time of the day has been chosen.
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