Active Ingredient: Efalizumab
Treatment of adult patients with moderate to severe chronic plaque psoriasis who have failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapies including ciclosporin, methotrexate and PUVA.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 0.7 milligrams efalizumab per kilogram of body weight, one dose, over the duration of 1 week. Afterwards, subcutaneous, 1 milligrams efalizumab per kilogram of body weight, once weekly, over the duration of 11 weeks.
An initial single dose of 0.7 mg/kg body weight is given followed by weekly injections of 1.0 mg/kg body weight (maximum single dose should not exceed a total of 200 mg). The volume to be injected should be calculated as follows:
| Dose | Volume to be injected per 10 kg body weight |
|---|---|
| Single initial dose: 0.7 mg/kg | 0.07 ml |
| Subsequent doses: 1 mg/kg | 0.1 ml |
The duration of therapy is 12 weeks. Therapy may be continued only in patients who responded to treatment (PGA good or better).
Injection sites should be rotated.
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