Severe hypoglycaemic reactions

Indication for Glucagon

Population group: Suitable for both men and women, only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Glucagon is indicated for treatment of severe hypoglycaemic reactions, which may occur in the management of insulin treated children and adults with diabetes mellitus.

For this indication, competent medicine agencies globally authorize below treatments:

0.5-1 mg once

For: Children Adolescents

Route of admnistration

Subcutaneous

Defined daily dose

0.5 - 1 mg per kg of body weight

Dosage regimen

From 0.5 To 1 mg per kg of body weight once every day

Detailed description

Administer 0.5 mg (children below 25 kg or younger than 6–8 years) or 1 mg (children above 25 kg or older than 6–8 years).

Dosage considerations

The patient will normally respond within 10 minutes. When the patient has responded to the treatment, give oral carbohydrate to restore the liver glycogen and prevent relapse of hypoglycaemia. If the patient does not respond within 10 minutes, intravenous glucose should be given.

0.5-1 mg once

For: Children Adolescents

Route of admnistration

Intravenous

Defined daily dose

0.5 - 1 mg per kg of body weight

Dosage regimen

From 0.5 To 1 mg per kg of body weight once every day

Detailed description

Administer 0.5 mg (children below 25 kg or younger than 6–8 years) or 1 mg (children above 25 kg or older than 6–8 years).

Dosage considerations

Onset of action after an intravenous injection of 0.2–0.5 mg occurs within one minute and the duration of effect is between 5 and 20 minutes. The onset of action after an intramuscular injection of 1–2 mg occurs after 5–15 minutes and lasts approximately 10–40 minutes.

1 mg once

For: Adults (18-64) Elders (65+)

Route of admnistration

Intramuscular

Defined daily dose

1 mg

Dosage regimen

1 mg once every day

Detailed description

Administer 1 mg by intramuscular injection.

Dosage considerations

The patient will normally respond within 10 minutes. When the patient has responded to the treatment, give oral carbohydrate to restore the liver glycogen and prevent relapse of hypoglycaemia. If the patient does not respond within 10 minutes, intravenous glucose should be given.

1 mg once

For: Adults (18-64) Elders (65+)

Route of admnistration

Subcutaneous

Defined daily dose

1 mg

Dosage regimen

1 mg once every day

Detailed description

Administer 1 mg by subcutaneous injection.

Dosage considerations

The patient will normally respond within 10 minutes. When the patient has responded to the treatment, give oral carbohydrate to restore the liver glycogen and prevent relapse of hypoglycaemia. If the patient does not respond within 10 minutes, intravenous glucose should be given.

Active ingredient

Glucagon is a hyperglycaemic agent that mobilises hepatic glycogen, which is released into the blood as glucose. Glucagon inhibits the tone and motility of the smooth muscle in the gastrointestinal tract.

Read more about Glucagon

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