Thyrotoxicosis

Active Ingredient: Propranolol

Indication for Propranolol

Population group: only children (1 year - 12 years old)

For this indication, competent medicine agencies globally authorize below treatments:

1-2 mg/kg in 4 divided doses daily

Route of admnistration

Oral

Defined daily dose

1 - 2 mg per kg of body weight

Dosage regimen

From 0.25 To 0.5 mg per kg of body weight 4 time(s) per day every day

Loading dose

1 mg per kg of body weight

Detailed description

Dosage should be determined according to the cardiac status of the patient and the circumstances necessitating treatment. The doses given are intended only as a guide: 0.25-0.5 mg/kg bodyweight three or four times daily as required.

Active ingredient

Propranolol

Propranolol is a competitive antagonist at both beta, and beta2-adrenoceptor, but has membrane stabilising activity at concentrations exceeding 1-3mg/litre, though such concentrations are rarely achieved during oral therapy. Competitive beta-blockade has been demonstrated in man by a parallel shift to the right in the dose-heart rate response curve to beta-agonists such as isoprenaline.

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