Hyperphosphataemia in patients with Chronic Kidney Disease (CKD) Stage 5

Active Ingredient: Colestilan

Indication for Colestilan

Population group: only adults (18 - 65 years old)
Therapeutic intent: Curative procedure

Colestilan is indicated for the treatment of hyperphosphataemia in adult patients with Chronic Kidney Disease (CKD) Stage 5 receiving haemodialysis or peritoneal dialysis.

For this indication, competent medicine agencies globally authorize below treatments:

6-12 g in three divided doses daily


Dosage regimens

Oral, between 6 grams colestilan and 12 grams colestilan, divided 3 times daily.

Detailed description

The recommended starting dose is 6-9 g per day (2-3 g three times daily).

Patients previously on other phosphate binders who are switched to BindRen should start taking 6-9 g per day (2-3 g three times daily).

Dose titration

Serum phosphorus concentrations should be monitored. If an acceptable serum phosphorus concentration is not achieved, the dose may be increased by 3 g per day (1 g three times daily) in 2-3 weekly intervals. The maximum daily dose of BindRen tested in clinical trials was 15 g per day (5 g three times daily).

Dosage considerations

The daily dose of should be taken in three equally divided doses with or immediately after meals with a sufficient amount of water to aid swallowing.

The division of the daily dose may be adjusted on a physician’s advice taking into account the dietary intake of phosphate. Patients should be encouraged to adhere to their prescribed low phosphate diets.

Treatment of high blood phosphorus levels usually requires long-term treatment.

Active ingredient


Colestilan is a non-absorbed, non-calcium, non-metallic phosphate-binding polymer. The binding sites become partially protonated in the stomach and interact through ionic and hydrogen bonding with both dietary phosphate anions and bile acids in the duodenum. By binding phosphate from food in the digestive tract, colestilan lowers the serum phosphorus concentration. Colestilan also binds bile acids, thereby lowering the serum LDL-cholesterol concentration.

Read more about Colestilan

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