Trigeminal neuralgia

Active Ingredient: Phenytoin

Indication for Phenytoin

Population group: only adults (18 years old or older)

Phenytoin has also been employed in the treatment of trigeminal neuralgia but it should only be used as second line therapy if carbamazepine is ineffective or patients are intolerant to carbamazepine.

For this indication, competent medicine agencies globally authorize below treatments:

300-500 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

300 - 500 mg

Dosage regimen

From 150 To 250 mg 2 time(s) per day every day

Detailed description

The clinically effective dose has not been established in clinical trials. In adults, 300-500 mg daily given in divided doses has been reported in the literature. Dosing should be adjusted based on clinical response. Determination of serum phenytoin levels is advised. Levels of total phenytoin should not exceed 20 mcg/ml.

Active ingredient

Phenytoin

Phenytoin is effective in various animal models of generalised convulsive disorders, reasonably effective in models of partial seizures but relatively ineffective in models of myoclonic seizures. It appears to stabilise rather than raise the seizure threshold and prevents spread of seizure activity rather than abolish the primary focus of seizure discharge.

Read more about Phenytoin

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