Active Ingredient: Lercanidipine
Lercanidipine is indicated for the treatment of mild to moderate essential hypertension.
For this indication, competent medicine agencies globally authorize below treatments:
Oral, 10 milligrams lercanidipine, once daily -15 minutes before breakfast. Afterwards, oral, between 10 milligrams lercanidipine and 20 milligrams lercanidipine, once daily -15 minutes before breakfast. The maximum allowed total dose is 20 milligrams lercanidipine daily.
The recommended dosage is 10 mg orally once a day at least 15 minutes before meals; the dose may be increased to 20 mg depending on the individual patient’s response. Dose titration should be gradual, because it may take about 2 weeks before the maximal antihypertensive effect is apparent.
Some individuals, not adequately controlled on a single antihypertensive agent, may benefit from the addition of lercanidipine to therapy with a beta-adrenoceptor blocking drug (atenolol), a diuretic (hydrochlorothiazide) or an angiotensin converting enzyme inhibitor (captopril or enalapril).
Since the dose-response curve is steep with a plateau at doses between 20-30 mg, it is unlikely that efficacy will be improved by higher doses; whereas side effects may increase.
Although the pharmacokinetic data and clinical experience suggest that no adjustment of the daily dosage is required, special care should be exercised when initiating treatment in the elderly.
Treatment should be preferably administered in the morning at least 15 minutes before breakfast.
It should not been administered with grapefruit juice.
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